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Gill is our resident pet health and nutrition expert who recently retired from a 14-year career in veterinary teaching to pursue writing and researching.

Importance of Anxiety Prevention

It’s immensely hard for a caring pet owner to witness their dog experiencing anxiety. Preventing anxiety from snowballing into destructive, aggressive or difficult behaviors is vital.

Anxiety in dogs comes in several different forms, such as fear-based (such as car rides, new environments or loud noises), separation anxiety (the inability to calm themselves when left alone), and age-based anxiety which worsens as they get older. Knowing how to prevent anxiety and alleviate your dog’s stress is a key part of their wellbeing.

Nature provides us with the perfect ingredients for soothing and easing our four-legged friends.

Symptoms of Anxiety in Dogs

Your dog is a unique being, so you will need to learn the signs of anxiety in your dog, which may be different from another. However, there are some common symptoms:

Destructive behavior
Aggression
Panting and drooling
Urinating/defecating inside
Low mood/depression
Excessive barking
Growling
Restlessness and/or pacing
Compulsive behaviors
Unsettled stomach, nausea and vomiting

Benefits of Chamomile Flower Powder & L-Tryptophan

Choosing natural ingredients with scientifically-proven benefits ensures you choose the right anti-anxiety supplement for your dog, to get him happy and content once more. Chamomile Flower Powder and L-Tryptophan have been shown to be enormously beneficial for anxious dogs:

High Quality Dog Anxiety Suplement:

Chamomile is known for being a natural gentle sedative.
Alleviates stress and promotes calm.
L-Tryptophan is converted into the feel good hormone, serotonin.
Serotonin brings a sense of ease, and aids sleep.
Works to reduce aggression.

What Ingredients to Look for in an Anxiety-Relief Supplement

It can be confusing to know what to give your dog to help alleviate their anxiety, and to help prevent it. We recommend choosing natural supplements with the following evidence-based ingredients:

Chamomile Flower Powder To naturally relieve the feelings of stress and anxiety.
L-Tryptophan To promote serotonin production to soothe and facilitate good sleep.
Ginger Root Powder To calm an anxious stomach and alleviate nausea.
Passion Flower Powder To help reduce anxiety and bring a feeling of ease.

What Ingredients To Avoid

When shopping for dog supplements with a healthy skin and coat in mind, avoid:

Manufactured Formulation Omega 3 Hydrolyzation is a process by which the amino acids in collagen are broken down by heated water so they’re easier for your body to absord. This method is also the safest and avoids the use of harsh chemicals.
Cod Liver Oil Some vets do not recommend cod liver oil as a source of omega-3 for dogs because it may lead to doses of Vitamins A and D which are too high.
Flaxseed Oil or Byproducts These will contain high amounts of alpha linolenic acid which can be difficult for dogs to convert to the required form. Hydrolyzation is a process by which the amino acids in collagen are broken down by heated water so they’re easier for your body to absord. This method is also the safest and avoids the use of harsh chemicals.

Our Checklist For a Dog Calming Supplement

These are some signs of a good quality product and may improve your chances of seeing results:

CloseOpen the Checklist

L-Tryptophan
L-Tryptophan is an essential ingredient as it helps the dog’s own system work more harmoniously to reduce anxiety.
Money-Back Guarantee
Be sure that you’re choosing a reliable and responsible brand by checking for a money-back guarantee.
Serving Sizes and Ingredient Levels
Natural ingredients are less likely to cause high levels of drowsiness compared to medications, but you still need to know the right amount to give based on size.
Tasty Chew
Anxious dogs do better with a tasty chew, rather than the additional stress of a pill.
All-Natural
Choose a supplement which uses all-natural ingredients to give your dog the best.

How We Evaluated the Top 5

Effectiveness
Ingredients
Value for Money
Customer Service

Top 5 Dog Calming Supplements of 2025

Calming ^{[ 1 ]}

by Pawfy

A+

OVERALL GRADE

TOTAL RANKING

Ingredient Safety
9.9AVG. 9.9/10
Projected Efectiveness
9.8AVG. 9.8/10
Value
9.7AVG. 9.7/10
Return Policy
9.5AVG. 9.5/10
Customer Satisfaction
9.6AVG. 9.6/10

Pros

High Dose of L-Tryptophan
Contains Passion Flower
Includes Chamomile
Made in USA from US & Global Ingredients
Soft Chew Form
30 Day Money Back Guarantee

Cons

Only Available Online or Amazon Only Available Online
Sometimes Out of Stock

The Bottom Line

Of every Calming supplement we’ve tested for dogs, Pawfy’s Calming Soft Chews have been shown to be one of the most effective, well-rounded formulas for easing your pup.

By combining potent doses of natural, high quality ingredients such as L-Tryptophan and Passion flower, their formula can help relax dogs without any drowsy side effects. By combining these ingredients with Chamomile, these chews can improve anxiety, stress, over-excitement or aggression in all dogs.

With the inclusion of Ginger Root Powder, they also have the added benefit of easing upset stomachs, nausea, motion sickness and as a result can help dogs during travel or other stressful events.

It is clear that Pawfy has one of the most robust anti-anxiety and calming formulas of all the brands we tested. Equally important is the fact that they are Made in the USA from US & Global Ingredients, come with a 30 Day Money Back Guarantee and Free Shipping, which allows readers to try them risk-free.

Overall, we have rated Pawfy as having the best Calming supplement on the market in 2025 from all those that we tested.

* Results are based on the our Subjective Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

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Calm with Melatonin

by Waggedy